Recent clinical studies have shown that molecular hydrogen is biologically active as an anti-inflammatory agent among chronic dialysis treatment and powerful oxidative stress. (Centers for Disease Control and Prevention)
Iron-induced oxidative stress has been found to be a central player in the pathogenesis of kidney injury. Recent studies have indicated H₂ can be used as a novel antioxidant to protect cells. In conclusion, hydrogen may attenuate CIH-induced renal injury at least partially via inhibiting renal iron overload. (Department of Physiology, Hebei University of Chinese Medicine)
The incidence of chronic graft‐versus‐host disease (cGVHD) is rising recent years, which has been the leading cause of mortality post transplantation. The study shows that molecular hydrogen has anti‐inflammatory, antioxidant, anti‐fibrosis effects.
It has been reported that hydrogen gas exerts a therapeutic effect in a wide range of disease conditions, from acute illness such as ischemia–reperfusion injury, shock, and damage healing to chronic illness such as metabolic syndrome, rheumatoid arthritis, and neurodegenerative diseases. Studies also suggest possible therapeutic effects of hydrogen gas in aspects of emergency and critical care medicine, such as acute myocardial infarction, cardiopulmonary arrest syndrome, contrast-induced acute kidney injury and hemorrhagic shock. (Department of Cardiology, Keio University School of Medicine, Tokyo, Japan, Oct 24th 2017)
Reactive oxygen species (ROS) impair neovascularization and perfusion recovery following limb ischemia in patients with peripheral arterial disease (PAD). Hydrogen molecules (H2) comprise an antioxidant gas that has been reported to neutralize cytotoxic ROS. H2 gas increases angiogenesis and arteriogenesis and subsequently improves perfusion recovery in a mouse PAD model via reduction of ROS levels.